Molecular Cell & Developmental Biology
225 Sinsheimer Laboratories
Phone: 831.459.4986
Fax: 831.459.3139
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MANUEL ARES, Jr. Professor of MCD Biology B. S., Cornell University Ph.D., University of California, San Diego Postdoctorate, Yale University School of Medicine ARES LAB

225 Sinsheimer Laboratories University of California Santa Cruz, CA 95064 phone 831.459.4628 fax 831.459.3139 ares@biology.ucsc.edu office hours

Intron Removal, Alternative Splicing, and Genomics
Our work centers on the mechanisms and regulation of splicing. Splicing is required to remove intron sequences from pre-mRNA and create coding sequences for translation.  We study yeast, mouse and human tissues and cells, as well as the malaria parasite Plasmodium falciparum.  We are generally interested in the structure and function of RNAs that play important regulatory and catalytic roles.

We try to understand (1) the mechanism of action of the core components of the spliceosome, in particular the snRNAs and their rearrangements during assembly of the spliceosome and catalysis of the splicing reactions (2) the regulation of alternative splicing at a mechanistic level including the coupling of splicing to transcription and RNA decay mechanisms, and (3) the coordinate regulation of splicing events in developing systems.

Recent Publications

Please search PubMed for the most up-to-date Ares lab publications.