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Molecular Cell & Developmental Biology
225 Sinsheimer Laboratories
Phone: 831.459.4986
Fax: 831.459.3139
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Manuel Ares, Jr.

MANUEL ARES, Jr.
Professor of MCD Biology
B. S., Cornell University
Ph.D., University of California, San Diego
Postdoctorate, Yale University School of Medicine

ARES LAB


 

225 Sinsheimer Laboratories
University of California
Santa Cruz, CA 95064
phone 831.459.4628
fax 831.459.3139
ares@biology.ucsc.edu

office hours

Intron Removal, Alternative Splicing, and Genomics
Our work centers on the mechanisms and regulation of splicing. Splicing is required to remove intron sequences from pre-mRNA and create coding sequences for translation.  We study yeast, mouse and human tissues and cells, as well as the malaria parasite Plasmodium falciparum.  We are generally interested in the structure and function of RNAs that play important regulatory and catalytic roles.

We try to understand (1) the mechanism of action of the core components of the spliceosome, in particular the snRNAs and their rearrangements during assembly of the spliceosome and catalysis of the splicing reactions (2) the regulation of alternative splicing at a mechanistic level including the coupling of splicing to transcription and RNA decay mechanisms, and (3) the coordinate regulation of splicing events in developing systems.

We are using microarrays that measure splicing, and are determining the effects of mutations or other perturbations on splicing. Our goal is to develop a broad understanding of the role of splicing in specific processes and biological events, at the level of genes whose function and regulation at the level of splicing may be difficult to discern by traditional methods.



Recent Publications

Please search PubMed for the most up-to-date Ares lab publications.


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